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传明酸联合丝心蛋白在小鼠烫伤创面的修复作用研究
Study on the Repair Effect of Tranexamic Acid Combined with Fibroin on Burn Wounds in Mice
吴梦;胡秀英;张雨彤;王晓东;马加翼;郑中博 WU Meng;HU Xiuying;ZHANG Yutong;WANG Xiaodong;MA jiayi;ZHENG Zhongbo目的：研究传明酸联合丝心蛋白制备的一款膏霜样品在浅II度烫伤的创面修复测试。方法：选择雄性昆明小鼠52只，随机分组，每组13只，分为空白对照组、模型对照组、阳性对照组、样品组;使用YLS-5Q超级控温烫伤仪制作小鼠背部浅II度烫伤模型，背部皮损处涂抹膏霜样品，记录创面愈合率、愈后瘢痕面积、炎症因子TNF-α表达水平。结果：与模型对照组相比，膏霜样品能显著提高创面愈合率，显著遏制愈后瘢痕面积；降低炎症因子TNF-α表达水平。结论：这款含有传明酸联合丝心蛋白的膏霜样品可以明显减小创面愈后瘢痕的面积，减少瘢痕的形成，对创伤后疤痕的防治具有重要的意义。
Objective:To evaluate the wound healing efficacy of a cream formulation containing tranexamic acid combined with fibroin in superficial second-degree burn models. Methods: Fifty-two male Kunming mice were randomly divided into four groups(13 per group): blank control, model control, positive control, and test sample group. Superficial second-degree burns were induced on the dorsal skin using a YLS-5Q super-temperature-controlled scalding instrument. The test cream was applied to the injured areas, and wound healing rate, post-healing scar area, and expression levels of the inflammatory cytokine TNF-α were recorded. Results:Compared with the model control group, the cream significantly improved wound healing rate, markedly reduced post-healing scar area, and decreased TNF-α expression levels. Conclusion:This cream formulation containing tranexamic acid and fibroin effectively reduces scar formation and minimizes scar size after wound healing, demonstrating significant potential for the prevention and treatment of post-traumatic scarring.
胶原蛋白肽燕窝酸粉对人体皮肤作用的研究
Effects of Collagen Peptide and Bird's Nest Acid Compound Powder on Facial Skin:A Randomized, Double-Blind, Placebo-Controlled Clinical Study
李成武;张雪锋;海陆宇;尚宇奇;艾华 LI Chengwu;ZHANG Xuefeng;HAI Luyu;SHANG Yuqi;AI Hua目的：研究一款以胶原蛋白肽和燕窝酸为主要成分的复方粉对人体面部皮肤状况的改善作用。方法：采用随机、双盲、安慰剂对照实验设计，将女性受试者随机分为实验组和对照组，分别服用受试品或安慰剂，连续8周。于服用前、服用4周和8周后分别进行功效指标测定。结果：与对照组相比，实验组服用复方粉8周后，脸颊角质层水分含量显著升高，经表皮失水率明显降低；皮肤光泽度、色泽度、平滑度和和粗糙度等相关指标得到一定程度改善；皮肤弹性指标得到明显好转，面部皱纹相关指标得到改观，真皮表皮的密度和厚度明显增加；双光子在体显微成像学4项指标明显向好。结论：胶原蛋白肽燕窝酸复方粉在保湿、紧致、抗皱、修复等方面对皮肤有改善作用。
Objective: To study the effects of a compound powder made mainly of collagen peptides and sialic acid from bird's nest on facial skin conditions in humans. Methods: A randomized, double-blind, placebo-controlled experiment was conducted. Female participants were randomly divided into a test group and a control group, taking either the test product or a placebo for 8 weeks. Efficacy indicators and related safety assessments were measured before intake, after 4 weeks and 8 weeks. Results: Compared with the placebo group, after 8 weeks of taking the collagen peptide and sialic acid compound powder, participants in the test group showed a significant increase in cheek stratum corneum moisture content and a marked reduction in transepidermal water loss; those indicators like skin glow, color, smoothness, and roughness have improved to some extent; skin elasticity has noticeably gotten better, and the facial wrinkle-related indicators have improved; the density and thickness of the dermis and epidermis have clearly increased; four indicators in two- photon in vivo microscopy imaging have significantly improved. Conclusion: The collagen peptide and sialic acid compound powder improves skin health through multi-dimensional effects, including hydration, firming, reducing wrinkles, and repairing.
潜在可适配热疗的美白祛斑功效按摩霜的制备及初步评价
Preparation and Preliminary Evaluation of a Potential Hyperthermia-Adapted Massage Cream with Whitening and Freckle-Removing Efficacy
张林梅;陆萍;杨宇婷;曾邦造;张伟禄 ZHANG Lin-mei;LU Ping;YANG Yu-ting;ZENG Bang-zao;ZHANG Wei-Lu本文以氨甲环酸和谷胱甘肽为核心美白功效成分，通过科学的配方设计，研发一款适配热疗场景的美白祛斑按摩霜。性能测试结果表明其理化性质稳定，皮肤刺激性低，具备良好的使用安全性。受试者持续使用14天后，面部斑点的数量减少，皮肤亮度提升，弹性增强，含水量增加，黑色素与血红素含量有效降低。研究结果证实了氨甲环酸与谷胱甘肽在美白祛斑方面具有良好的协同作用，两者复配开发的按摩霜可实现安全且有效的美白祛斑效果，适配热疗的产品定位也为其应用拓展了场景，有望作为热疗辅助用护肤产品为面部色斑、肤色不均等肌肤问题的改善提供新的解决方案与研究思路。
Tranexamic Acid and Glutathione were used as the core whitening functional ingredients to develop a whitening and freckle-removing massage cream suitable for thermotherapy scenarios through scientific formula design in this study. Performance characterization of the massage cream showed that it had stable physicochemical properties and low skin irritation, with good application safety. To verify its practical application effects, a human trial was conducted. After the subjects continuously used the product for 14 days, the number of facial freckles showed a significant decreasing trend; meanwhile, multiple skin indicators were remarkably improved, including increased skin brightness, enhanced elasticity, higher water content, and effectively reduced contents of melanin and heme. The research results confirm that Tranexamic Acid and Glutathione have a favorable synergistic effect in whitening and freckle removal. The massage cream developed based on the compounding of the two ingredients can achieve safe and effective whitening and freckle-removing effects, and its product positioning adapted to thermotherapy also expands its application scenarios. It is expected to be used as a skin care product auxiliary to thermotherapy, providing a new solution and research idea for improving skin problems such as facial pigmentation and uneven skin tone.
基于网络药理学解析壮药治疗湿瘀互结寻常痤疮的“成分-靶点-通路”多维作用机制
Multidimensional 'Component-target-pathway' Mechanism of Zhuang Medicine in Treating Dampness-stasis Acne Vulgaris Based on Network Pharmacology
林舟;梁晓梅;关扬;何国栋;王露瑶 LIN Zhou;LIANG Xiaomei;GUAN Yang;HE Guodong;WANG Luyao目的：基于壮医理论，运用网络药理学与分子对接技术，探讨土茯苓、薏苡仁、黄连、麻柳叶、南酸枣五味壮药治疗湿瘀互结型寻常痤疮的潜在机制。方法：通过TCMSP、HERB、SwissTargetPrediction等数据库筛选活性成分及靶点；从GeneCards、OMIM、TTD等数据库获取痤疮相关靶点；构建药物-活性成分-靶点网络及蛋白互作网络，进行GO功能与KEGG通路富集分析，并采用分子对接验证关键成分与核心靶点的结合能力。结果：共获得活性成分37种，药物靶点795个，痤疮相关靶点2201个，交集靶点158个；关键活性成分为槲皮素、小檗碱、β-谷甾醇等；核心靶点包括TNF、PTGS2、IL2、AKT1、EGFR、VEGFA、STAT3、JAK2、PPARG、MMP9；富集分析主要涉及肿瘤通路、AGE-RAGE信号通路、脂质与动脉粥样硬化、PI3K-Akt等炎症与脂质代谢相关通路；分子对接结果表明β-谷甾醇、槲皮素等与核心靶点结合较强，其中β-谷甾醇与PPARG结合能为-10.0kcal/mol。结论：五味壮药可能通过多成分、多靶点、多通路协同调控炎症反应、脂质代谢及微循环，发挥解毒祛瘀、利湿散结作用，初步揭示壮医理论与现代病理机制的关联，为该类壮药植物提取物在祛痘化妆品中的应用提供依据。本文同时发表于《中国化妆品科学》期刊与《中国抗衰老化妆品学术论坛》学术会议论文集，为同一成果的联合出版，不视为两篇独立学术成果。
Objective: Based on the Zhuang medicine theory, this study employs network pharmacology and molecular docking techniques to explore the potential mechanisms of five Zhuang medicinal herbs— Smilax glabra, Coix lacryma-jobi, Coptis chinensis, Pterocarya stenoptera, and Choerospondias axillaris— in the treatment of dampness-stasis intermingled type acne vulgaris.Methods: Active components and their targets were screened using TCMSP (Traditional Chinese Medicine Systems Pharmacology Database), HERB (High-throughput Experimental and Reference-assisted Browser), SwissTargetPrediction, and other databases. Acne-related targets were obtained from GeneCards, OMIM (Online Mendelian Inheritance in Man), and TTD (Therapeutic Target Database). A drug-active component-target network and a PPI (protein-protein interaction) network were constructed. GO (Gene Ontology) functional and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analyses were performed, and molecular docking was used to validate the binding affinity between key components and core targets.Results: A total of 37 active components, 795 drug targets, 2,201 acne-related targets, and 158 intersecting targets were identified. Key active components included quercetin, berberine, and β-sitosterol. Core targets included TNF (tumor necrosis factor), PTGS2 (prostaglandin-endoperoxide synthase 2), IL2 (interleukin-2), AKT1 (AKT serine/threonine kinase 1), EGFR (epidermal growth factor receptor), VEGFA (vascular endothelial growth factor A), STAT3 (signal transducer and activator of transcription 3), JAK2 (Janus kinase 2), PPARG (peroxisome proliferator-activated receptor gamma), and MMP9 (matrix metallopeptidase 9). Enrichment analyses mainly involved pathways related to cancer, the AGE-RAGE (advanced glycation end products-receptor for advanced glycation end products) signaling pathway, lipid and atherosclerosis, and the PI3K-Akt (phosphatidylinositol 3-kinase-protein kinase B) signaling pathway, all associated with inflammation and lipid metabolism. Molecular docking results demonstrated strong binding affinities of β-sitosterol and quercetin with core targets, with β-sitosterol showing a binding energy of −10.0 kcal/mol to PPARG.Conclusion: The five Zhuang medicinal herbs may synergistically regulate inflammatory responses, lipid metabolism, and microcirculation through multi-component, multi- target, and multi-pathway mechanisms, exerting detoxifying, stasis-removing, dampness-draining, and nodule- dissipating effects. This study preliminarily establishes a connection between Zhuang medicine theory and modern pathological mechanisms, providing a basis for the application of extracts from these Zhuang medicinal plants in anti-acne cosmetic products.
天然抗皱复合原料功效评价及研究
Efficacy Evaluation and Research on Natural Anti-Wrinkle Composite Raw Materials
苑春艳;丁振柱;刘含亮;张其鑫 YUAN Chunyan;DING Zhenzhu;LIU Hanliang;ZHANG Qixin筛选具有抗皱、抗氧化活性的天然成分与功能多肽，构建高效协同的天然抗皱复合原料体系，为抗皱化妆品开发提供实验依据与应用方案。选取红景天苷、倒捻子素、植醇、二氢杨梅素、棕榈酰三肽-1为候选原料，采用体外生化实验与皮肤成纤维细胞模型开展筛选及复配研究；以弹性蛋白酶抑制率评价抗皱功效，以DPPH、ABTS自由基清除率评估抗氧化活性；在细胞层面检测I型胶原蛋白合成量及基质金属蛋白酶-1（MMP-1）、基质金属蛋白酶-3（MMP-3）分泌水平，明确其抗皱作用机制。本研究构建的新型天然抗皱复合原料可显著清除DPPH与ABTS自由基，有效抑制弹性蛋白酶活性；同时能显著上调皮肤成纤维细胞中I型胶原蛋白合成，下调MMP-1、MMP-3表达水平。天然成分与多肽复配体系可通过多靶点协同作用，同步实现抗氧化、抑制弹性蛋白酶降解、促进胶原合成、抑制基质金属蛋白酶表达，具备良好的抗皱与紧致功效，为抗皱化妆品研发提供了可靠的实验基础与应用方案。
To create a highly synergistic anti-wrinkle composite system, screen natural ingredients and functional peptides with antioxidant and anti-wrinkle properties, and offer experimental support and application strategies for the creation of anti-wrinkle cosmetics. As potential materials, salidroside, mangostin, phytol, dihydromyricetin, and palmitoyl tripeptide-1 were chosen. Research on compound formulation and ingredient screening was conducted using human skin fibroblast models and in vitro biochemical assays. Elastase inhibition rate was used to measure anti-wrinkle efficacy, and DPPH and ABTS free radical scavenging rates were used to measure antioxidant activity. At the cellular level, the synthesis of type I collagen as well as the secretion levels of matrix metalloproteinase1 (MMP1) and matrix metalloproteinase3 (MMP3) were determined to elucidate the antiwrinkle mechanism. The novel antiwrinkle composite prepared in this study can effectively scavenge DPPH and ABTS free radicals and markedly inhibit elastase activity. Meanwhile, it significantly upregulates type I collagen synthesis and downregulates the expression of MMP1 and MMP3 in skin fibroblasts. This composite system consisting of natural active ingredients and peptides exerts antioxidant, antiwrinkle and skinfirming effects via multitarget synergistic actions. It works by simultaneously scavenging free radicals, restraining elastasemediated degradation, boosting collagen synthesis and suppressing matrix metalloproteinase expression. These findings provide a reliable experimental basis and application strategy for the research and development of antiwrinkle cosmetics.
